In today’s world, the cultivation of innovative and entrepreneurial talents has become a key factor affecting the country’s core competitiveness. Innovation and entrepreneurship education is becoming a brand-new model pursued by higher education. However, most colleges and universities only work hard to continuously build and improve the innovation and entrepreneurship curriculum system. However, there is no good solution for how to integrate the cultivation of innovation and entrepreneurship ability with engineering education, and how to integrate the cultivation of innovation ability with industry needs. Faced with this problem, this article explores a set of teaching reform solutions that integrate innovative and entrepreneurial thinking and methods into professional practice courses. In the practice of professional courses, it collects real industry needs from school-enterprise cooperative enterprises, guides students' innovation direction and goals, and introduces TRIZ innovative methods to improve the level of innovative design. At the same time, the company's project implementation process and management methods are introduced into the practical training to improve the quality of the results in the design concept and system realization stage, and effectively enhance the students' innovation motivation and practical ability. Through the verification of the pilot course, this teaching reform method can effectively integrate innovative and entrepreneurial thinking methods with the majors learned, enhance the students' teamwork and knowledge integration and application capabilities, and can significantly improve the level of innovation in practical courses.